An Ehrlich-inspired retrobiosynthesis of pharmaceutical scaffolds
Anastasia E.C. Rumpl, Devin Kowalski, Joshua R. Goodhew, Mika Hirano, Liam Bogucki, Carlos A. Rosa, Marc‐André Lachance, Michael E. Pyne
The paper repurposes the yeast Ehrlich pathway to synthesize pharmaceutical alkaloids using retrobiosynthetic analysis and enzyme screening.
bioRxiv · Nov 10, 2025 · PreprintSynthetic Biology