The Alzheimer's disease-associated rs28834970 variant in PTK2B impairs electrical activity and regulates Tau phosphorylation and APP processing in human neuronal cultures
Nina lannette-Weimann, Marlène Huyvaert, Floriane Limoge, Morgane Lemaire, Vance Difan Gao, Florence Maurier, Karine Guyot, Charlotte Henocq, Audrey Coulon, Valérie Buiche, Florian Rabiller, Nad’a Majerníková, Pauline Walle, Sophie Desnoulez-Salomé, Bruno Neiva-Queirós, , Julie Dumont
This study identifies the rs28834970 variant in PTK2B as a risk factor for Alzheimer's disease, showing it impairs PYK2 function, increases Tau phosphorylation, and alters APP processing in human neuronal cultures.
bioRxiv · Oct 30, 2026 · PreprintGenetics