Identification of a series of pyrrolo-pyrimidine based SARS-CoV-2 Mac1 inhibitors that repress coronavirus replication
Jessica J. Pfannenstiel, Men Thi Hoai Duong, Daniel Cluff, Lavinia M. Sherrill, Iain R. Colquhoun, Gabrielle Cadoux, Devyn Thorne, Johan Pääkkönen, Nathaniel F. Schemmel, Joseph O’Connor, Pradtahna Saenjamsai, Mei Feng, Srivatsan Parthasarathy, Michael J. Hageman, David K. Johnson, , Anthony R. Fehr
This study identifies pyrrolo-pyrimidine-based Mac1 inhibitors that inhibit MHV and SARS-CoV-2 replication, with some compounds showing IFN-dependent antiviral activity.
mBio · May 23, 2025Peer-reviewedMicrobiology