A molecular stabiliser of an inhibitory eIF2B-eIF2(αP) complex activates the Integrated Stress Response
Fiona Shilliday, Miguel Gancedo-Rodrigo, Ginto George, Shintaro Aibara, Santosh Adhikari, Syedah Neha Ashraf, Evelyne J. Barrey, Damian C. Crowther, Paige Dickson, Diana Gikunju, Marie-Aude Guié, John P. Guilinger, Anders Gunnarsson, Heather P. Harding, Christopher D. Hupp, , John E. Linley
The paper identifies a chemical inhibitor of eIF2B that activates the Integrated Stress Response by stabilizing an inhibitory complex with phosphorylated eIF2.
Nature Communications · May 6, 2026Peer-reviewedMolecular Biology