Author

Santosh Adhikari

AstraZeneca (United Kingdom)ORCID 0000-0002-1501-2106Unclaimed ORCID profile · follow to get notified of new preprints

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Santosh Adhikari1 paper

Biology Disciplines

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Molecular Biology· 2

Signature Assays, Organisms & Methods

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Assay:ChIP-seq· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Organism:human· 1 Approach:statistical model· 1

Frequent Co-Authors

Alisa F. ZyryanovaiD· 1 shared Anders GunnarssoniD· 1 shared Anthony D. KeefeiD· 1 shared Charles Antony AiD· 1 shared Christopher D. HuppiD· 1 shared D.A. StringfellowiD· 1 shared Damian C. CrowtheriD· 1 shared David John BakeriD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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1 shared paperMolecular Biology

Alisa F. ZyryanovaORCID

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2 papers

Recent·Most cited

Lineage-specific transcription factor CEBPA accelerates RNA Polymerase I dynamics

Charles Antony A, Santosh Adhikari, Subin S. George, Taejun Son, Kaeli M. Mathias, Frédéric Lessard, Tom Moss, Mustafa Mir, Vikram R. Paralkar

This study shows that the myeloid transcription factor CEBPA accelerates RNA Polymerase I dynamics at rDNA repeats by modulating promoter escape, Pol I accumulation, and DNA supercoiling resolution.

bioRxiv · Oct 27, 2026 · PreprintMolecular Biology

A molecular stabiliser of an inhibitory eIF2B-eIF2(αP) complex activates the Integrated Stress Response

Fiona Shilliday, Miguel Gancedo-Rodrigo, Ginto George, Shintaro Aibara, Santosh Adhikari, Syedah Neha Ashraf, Evelyne J. Barrey, Damian C. Crowther, Paige Dickson, Diana Gikunju, Marie-Aude Guié, John P. Guilinger, Anders Gunnarsson, Heather P. Harding, Christopher D. Hupp, , John E. Linley

The paper identifies a chemical inhibitor of eIF2B that activates the Integrated Stress Response by stabilizing an inhibitory complex with phosphorylated eIF2.

Nature Communications · May 6, 2026Peer-reviewedMolecular Biology