Shintaro Aibara

The paper identifies a chemical inhibitor of eIF2B that activates the Integrated Stress Response by stabilizing an inhibitory complex with phosphorylated eIF2.

The paper reports the cryo-EM structure of a transcribing Pol II-U1 snRNP complex with DSIF and SPT6, showing how phosphorylated Pol II and SPT6 interact with U1 snRNP to facilitate spliceosome assembly and transcription processivity.

The paper determines the structure of the human Mediator-RNA polymerase II transcription pre-initiation complex using cryo-EM, revealing interactions and conformational changes involved in transcription initiation.

The paper reports the cryo-EM structure of a mammalian transcribing RNA polymerase II-U1 snRNP complex and describes its role in co-transcriptional splicing.

The paper uses cryo-EM to study the structure of the fungal pyruvate dehydrogenase complex, revealing two PX oligomer arrangements that explain stoichiometry variation and suggest therapeutic targets.