Heather P. Harding

A molecular stabiliser of an inhibitory eIF2B-eIF2(αP) complex activates the Integrated Stress Response

The paper identifies a chemical inhibitor of eIF2B that activates the Integrated Stress Response by stabilizing an inhibitory complex with phosphorylated eIF2.

Metabolite import via SLC33A1 enables ATF6 activation by endoplasmic reticulum stress

This study identifies SLC33A1 as a key regulator of ATF6 activation by ER stress, showing its role in metabolite transport and glycan processing.

A homozygous p.(Arg371Ser) mutation in FICD de-regulates AMPylation of the human endoplasmic reticulum chaperone BiP causing infancy-onset diabetes and severe neurodevelopmental delay

Binding of the integrated stress response inhibitor, ISRIB, reveals a regulatory site in the nucleotide exchange factor, eIF2B

The paper identifies an ISRIB-binding site in eIF2B using cryo-EM and CRISPR/Cas9, showing its role in regulating translation through an allosteric mechanism.