Author

Malgorzata Anna Zal

The University of Texas MD Anderson Cancer CenterORCID 0000-0002-1015-3954Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Organism:human· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Collene R. JeteriD· 2 shared Philip L. LorenziiD· 2 shared Alessandro CarugoiD· 1 shared Andrea VialeiD· 1 shared Angela K. DeemiD· 1 shared Ben VanderkrukiD· 1 shared Brad G. HoffmaniD· 1 shared Brenda MelendeziD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersCancer Biology

Collene R. JeterORCID

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2 papers

Recent·Most cited

Mitochondrial defects and metabolic vulnerabilities in Lynch syndrome-associated MSH2-deficient endometrial cancer

Mikayla Borthwick Bowen, Brenda Melendez, Qian Zhang, Diana Moreno, Leah Peralta, WaiKin Chan, Collene R. Jeter, Lin Tan, Malgorzata Anna Zal, Philip L. Lorenzi, Kenneth Dunner, Richard Kenneth Yang, Russell R. Broaddus, Joseph Celestino, Nisha Gokul, , Melinda S. Yates

This study identifies mitochondrial dysfunction and metabolic reprogramming in MSH2-deficient endometrial cancer, revealing a novel pathway and potential therapeutic targets.

JCI Insight · Feb 18, 2025Peer-reviewedCancer Biology

WRAD core perturbation impairs DNA replication fidelity promoting immunoediting in pancreatic cancer

Francesca Citron, I-Lin Ho, Chiara Balestrieri, Zhaoliang Liu, Er-Yen Yen, Luca Cecchetto, Luigi Perelli, Li Zhang, Luis A Castillo, Nicholas Blazanin, Charles A. Dyke, Rutvi Shah, Sergio Attanasio, Sanjana Srinivasan, Ko‐Chien Chen, , Giulio Francesco Draetta

This study shows that disrupting the WRAD core in pancreatic cancer leads to DNA replication errors, immune response activation, and improved response to immune checkpoint inhibitors.

bioRxiv · Oct 21, 2024 · PreprintCancer Biology