Curing autoimmune diabetes with islet and hematopoietic cell transplantation after CD117 antibody-based conditioning
Preksha Bhagchandani, Stephan A. Ramos, Bianca Rodriguez, Xueying Gu, Shiva Pathak, Yuqi Zhou, Yujin Moon, Nadia Nourin, Charles Chang, Jessica Poyser, Brenda J. Velasco, Weichen Zhao, Hye-Sook Kwon, Richard Rodríguez, Diego Burgos, , Seung K. Kim
This study demonstrates that non-myeloablative conditioning with anti-CD117 antibodies and HCT can induce durable mixed chimerism and cure autoimmune diabetes in NOD mice.
bioRxiv · Sep 5, 2025 · PreprintImmunology