Charles Chang

This study demonstrates that non-myeloablative conditioning with anti-CD117 antibodies and HCT can induce durable mixed chimerism and cure autoimmune diabetes in NOD mice.

This study investigates how HNF1A regulates human islet cell function by combining genetic, transcriptomic, and functional assays, revealing its role in maintaining insulin and glucagon secretion.

Portal integrates large-scale single-cell datasets efficiently and accurately by preserving biological variation across samples, platforms, and species.

Nearly 500,000 cells from 24 human tissues, many from one donor, characterize over 400 cell types and enable within-donor study of T-cell clones, B-cell mutation rates and splicing.

This study investigates pig pancreatic islet development, identifying similarities with human islet ontogeny and uncovering signaling pathways relevant to beta-cell maturation.