Xueying Gu

Improved conditioning for hematopoietic chimerism induces islet tolerance to cure diabetes

This study identifies a conditioning regimen that promotes mixed hematopoietic chimerism and islet tolerance to cure diabetes in mice with minimal radiation.

Curing autoimmune diabetes with islet and hematopoietic cell transplantation after CD117 antibody-based conditioning

This study demonstrates that non-myeloablative conditioning with anti-CD117 antibodies and HCT can induce durable mixed chimerism and cure autoimmune diabetes in NOD mice.

HNF1α transcriptional activation and repression maintain human islet α and β cell function

This study investigates how HNF1A regulates human islet cell function by combining genetic, transcriptomic, and functional assays, revealing its role in maintaining insulin and glucagon secretion.

Molecular hallmarks of heterochronic parabiosis at single cell resolution

This study uses single-cell RNA-sequencing to analyze cell type-specific responses to young or aged blood in heterochronic parabiosis, identifying mitochondrial function as a key factor in rejuvenation.

SIX2 and SIX3 coordinately regulate functional maturity and fate of human pancreatic β-cells

This study shows that SIX2 and SIX3 regulate functional maturity and fate of human pancreatic β-cells, with SIX2 affecting insulin processing and glucose sensing, and SIX3 influencing gene expression patterns.

Molecular and genetic regulation of pig pancreatic islet cell development

This study investigates pig pancreatic islet development, identifying similarities with human islet ontogeny and uncovering signaling pathways relevant to beta-cell maturation.