Intravenous lipid-siRNA conjugate mediates gene silencing at the blood-brain barrier and blood-CSF barrier
Alexander G. Sorets, Katrina R Schwensen, Nora Francini, Andrew Kjar, Sarah Lyons, Joshua C. Park, Dillon Palmer, Adam M Abdulrahman, Rebecca P. Cowell, Ketaki A. Katdare, Ella N. Hoogenboezem, Angela Yee‐Moon Wang, Alexander P Ligocki, Rebecca Embalabala, Neil Dani, , Ethan S. Lippmann
This paper demonstrates that an intravenous lipid-siRNA conjugate can deliver gene silencing to brain barriers without affecting parenchymal tissue.
Journal of Controlled Release · Sep 11, 2025Peer-reviewedBioengineering