Neil Dani

Microvascular architecture and dynamics of the choroid plexus brain barrier

This study characterizes the vascular structure and function of the choroid plexus using multimodal techniques, revealing developmentally distinct endothelial subtypes and mechanosensitive properties.

Pcdh20 is a POU2F3 target gene required for proper tuft cell microvillus organization

This study identifies Pcdh20 as a POU2F3 target gene essential for tuft cell microvillus structure, showing its role in maintaining microvillar rigidity and organization.

Intravenous lipid-siRNA conjugate mediates gene silencing at the blood-brain barrier and blood-CSF barrier

This paper demonstrates that an intravenous lipid-siRNA conjugate can deliver gene silencing to brain barriers without affecting parenchymal tissue.

Natural language processing charts transcriptome evolution to design combination cancer therapies

This paper introduces RECODR, a computational pipeline that tracks transcriptome changes in cancer development and treatment to predict resistance mechanisms and design effective therapies.

A choroid plexus apocrine secretion mechanism shapes CSF proteome and embryonic brain development

The paper shows that apocrine secretion by the choroid plexus affects CSF proteome and brain development in mice, with maternal stressors disrupting this process.

A cellular and spatial map of the choroid plexus across brain ventricles and ages

This study constructs a single-cell and spatial atlas of the choroid plexus in developing and adult mice, revealing cell types, regional gene expression, and cell-cell interactions.

MEIS-WNT5A axis regulates development of 4th ventricle choroid plexus

This study identifies the MEIS-WNT5A axis as critical for the development and morphology of the fourth ventricle choroid plexus.