Targeted inhibition of Bcl-xL following radiation reduces tumourigenesis in preclinical models of H3K27M-altered diffuse midline glioma
Ashley Vardon, Scott Haston, Romain Guiho, Diana Carvahlo, Rebecca Carter, Jessica K.R. Boult, Daniel Gharai, Diwakar Santhakumar, Ielyaas Cloete, James Gray, John Richard Apps, Olumide Kayode Ogunbiyi, Daohong Zhou, Guangrong Zheng, Ramón Martínez‐Máñez, , Juan Pedro Martı́nez-Barberá
This study shows that combining radiation with Bcl-xL inhibition reduces tumor growth in preclinical models of H3K27M-altered diffuse midline glioma.
bioRxiv · Dec 20, 2024 · PreprintCancer Biology