CASC3 promotes transcriptome-wide activation of nonsense-mediated decay by the exon junction complex
Jennifer V. Gerbracht, Volker Boehm, Thiago Britto‐Borges, Sebastian Kallabis, Janica L. Wiederstein, Simona Ciriello, Dominik Aschemeier, Marcus Krüger, Christian Karl Frese, Janine Altmüller, Christoph Dieterich, Niels H. Gehring
This study shows that CASC3 enhances NMD by linking the EJC to the NMD machinery, leading to increased degradation of NMD-targeted mRNAs.
Nucleic Acids Research · Jul 1, 2020Peer-reviewedMolecular Biology