Molecular dissection of pro-fibrotic signaling identifies the mechanism underlying IL11-driven fibrosis gene translation, reveals non-specific effects of STAT3 and suggests a new mechanism of action for nintedanib
Anissa Anindya Widjaja, Sivakumar Viswanathan, Dong Jinrui, Brijesh Kumar Singh, Jessie Tan, Joyce Wei Ting Goh, David J. Lamb, Shamini Guna Shekeran, Benjamin L. George, Sebastian Schäfer, David Carling, Eleonora Adami, Stuart A. Cook
The paper investigates IL11-driven fibrosis mechanisms, showing ERK, not STAT3, drives fibrogenesis and identifies a novel role for nintedanib in inhibiting pro-fibrotic translation.
bioRxiv · Jun 10, 2021 · PreprintMolecular Biology