Author
National University of SingaporeORCID 0000-0001-9313-4195Unclaimed ORCID profile · follow to get notified of new preprints
Mutual co-authors in cluster
4 papers
Recent·Most cited
Anissa Anindya Widjaja, Wei‐Wen Lim, Sivakumar Viswanathan…·Stuart A. Cook
This study shows that inhibiting IL11 improves healthspan in aged mice by reversing metabolic dysfunction, sarcopenia, and frailty.
Anissa Anindya Widjaja, Sonia Pankaj Chothani, Sivakumar Viswanathan…·Stuart A. Cook
This study shows IL11 promotes inflammation in fibroblasts by upregulating IL33 and other proinflammatory genes, with STAT3 signaling being critical for this effect.
Anissa Anindya Widjaja, Joyce Wei Ting Goh, Sivakumar Viswanathan…·Stuart A. Cook
This study identifies IL11's role in inhibiting LKB1/AMPK and activating mTOR through ERK/P90RSK, leading to metabolic dysfunction and fibrosis in multiple cell types and NASH in mice.
Anissa Anindya Widjaja, Sivakumar Viswanathan, Dong Jinrui…·Stuart A. Cook
The paper investigates IL11-driven fibrosis mechanisms, showing ERK, not STAT3, drives fibrogenesis and identifies a novel role for nintedanib in inhibiting pro-fibrotic translation.