α-synuclein fibril and synaptic vesicle interactions lead to vesicle destruction and increased uptake into neurons
Amberley D. Stephens, Ana Fernández‐Villegas, Chyi Wei Chung, Oliver Vanderpoorten, Dorothea Pinotsi, Ioanna Mela, Edward Ward, Thomas M. McCoy, R. Cubitt, Alexander F. Routh, Clemens F. Kaminski, Gabriele S. Kaminski Schierle
This study investigates how monomeric and fibrillar alpha-synuclein interact with synaptic vesicles, showing fibrils disintegrate vesicles and increase neuronal uptake, potentially contributing to Parkinson's disease pathology.
bioRxiv · Oct 4, 2022 · PreprintNeuroscience