Local ionic conditions modulate the aggregation propensity and influence the structural polymorphism of alpha-synuclein
Maria Zacharopoulou, Neeleema Seetaloo, James F. Ross…·Gabriele S. Kaminski Schierle
This study investigates how Ca2+ and Na+ ions affect alpha-synuclein aggregation and fibril polymorphism, revealing their distinct roles in modulating conformational dynamics and structural outcomes.