Giada Lavigna

AAV-mediated SIL1 gene therapy prevents cerebellar degeneration and ataxia in a mouse model of Marinesco-Sjögren syndrome by preserving Purkinje cells and reducing ER stress.

This paper identifies elacridar as a compound that prevents prion infection by enhancing lysosomal function, showing effects against PrPSc, α-synuclein, and tau prions.

This study tests trazodone, dibenzoylmethane, and tauroursodeoxycholic acid in MSS mice but finds no prevention of motor dysfunction or neurodegeneration.