Roberto Chiesa

AAV-mediated SIL1 gene therapy prevents cerebellar degeneration and ataxia in a mouse model of Marinesco-Sjögren syndrome by preserving Purkinje cells and reducing ER stress.

This paper identifies elacridar as a compound that prevents prion infection by enhancing lysosomal function, showing effects against PrPSc, α-synuclein, and tau prions.

This study tests trazodone, dibenzoylmethane, and tauroursodeoxycholic acid in MSS mice but finds no prevention of motor dysfunction or neurodegeneration.

This study investigates the role of SUMO2/3 modification in mitigating Tau-induced synaptic and cognitive dysfunction in disease models.

This study shows that misfolded tau from traumatic brain injury induces toxicity in C. elegans, suggesting it drives functional decline rather than just being a marker of neurodegeneration.

This paper quantifies the challenges of designing preventive clinical trials for genetic prion disease due to high variability in age of onset, suggesting the need for biomarker-based trials.