Jean R.P. Gatdula

This paper demonstrates that the G127V prion protein variant can prevent and suppress prion infection through a dominant-negative effect, suggesting its potential as a therapeutic strategy.

This paper investigates the role of membrane-anchored PrPSc in prion-induced synaptotoxicity and shows that preventing its formation reduces synaptic damage.

This paper identifies elacridar as a compound that prevents prion infection by enhancing lysosomal function, showing effects against PrPSc, α-synuclein, and tau prions.

This study shows that N-linked glycans on PrPC are essential for maintaining a non-toxic structure and suppressing neurotoxicity through intramolecular interactions.