Author

Douglas M. Roberts

University of Warwick

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:bacteria (other)· 1

Frequent Co-Authors

Gregory L. ChallisiD· 2 shared Lona M. AlkhalafiD· 2 shared Munro PassmoreiD· 2 shared Xinyun JianiD· 2 shared Chuan HuangiD· 1 shared David P. FairlieiD· 1 shared Edward MarschalliD· 1 shared Emmanuel L. C. de los SantosiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersBiochemistry

Gregory L. ChallisORCID

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2 papers

Recent·Most cited

Molecular basis for depsipeptide HDAC inhibitor combinatorial biosynthesis

Munro Passmore, Xinyun Jian, Xinyi Zhao, Emmanuel L. C. de los Santos, Douglas M. Roberts, Józef Romuald Lewandowski, Matthew Jenner, Lona M. Alkhalaf, Gregory L. Challis

The paper identifies a novel subunit docking mechanism in depsipeptide HDAC inhibitor biosynthesis using gene proximity searching and experimental validation.

Nature Communications · Jul 1, 2026Peer-reviewedBiochemistry

Nitrogen deletion in the biosynthesis of HDAC-targeting anticancer drugs

Xinyun Jian, Jinlian Zhao, Edward Marschall, Kai‐Chen Wu, Chuan Huang, Munro Passmore, Douglas M. Roberts, David P. Fairlie, Max J. Cryle, Lona M. Alkhalaf, Gregory L. Challis

The paper investigates nitrogen deletion in the biosynthesis of HDAC-targeting anticancer drugs, showing its importance for bioactivity and revealing the enzymatic mechanisms involved.

bioRxiv · Mar 13, 2025 · PreprintBiochemistry