Author

Munro Passmore

University of WarwickORCID 0000-0002-7065-9682Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:bacteria (other)· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Assay:metabolomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Gregory L. ChallisiD· 3 shared Lona M. AlkhalafiD· 3 shared Douglas M. Roberts· 2 shared Józef Romuald LewandowskiiD· 2 shared Xinyun JianiD· 2 shared Alex J. MullinsiD· 1 shared Callum J Bullock· 1 shared Chuan HuangiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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3 shared papersBiochemistry

Gregory L. ChallisORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Molecular basis for depsipeptide HDAC inhibitor combinatorial biosynthesis

Munro Passmore, Xinyun Jian, Xinyi Zhao, Emmanuel L. C. de los Santos, Douglas M. Roberts, Józef Romuald Lewandowski, Matthew Jenner, Lona M. Alkhalaf, Gregory L. Challis

The paper identifies a novel subunit docking mechanism in depsipeptide HDAC inhibitor biosynthesis using gene proximity searching and experimental validation.

Nature Communications · Jul 1, 2026Peer-reviewedBiochemistry

Substrate scope and catalytic mechanism of α, β-epoxyketone synthase EpnF illuminated by in-situ esterase-mediated deprotection

Callum J Bullock, Marlene L. Rothe, Joshua W. Cartwright, Munro Passmore, Alex J. Mullins, Fabrizio Alberti, Józef Romuald Lewandowski, Lona M. Alkhalaf, Gregory L. Challis

This paper develops an esterase-mediated strategy to generate unstable substrates for EpnF, revealing its broad substrate tolerance and catalytic mechanism for epoxyketone synthesis.

ACS Catalysis · Jun 25, 2026Peer-reviewedBiochemistry

Nitrogen deletion in the biosynthesis of HDAC-targeting anticancer drugs

Xinyun Jian, Jinlian Zhao, Edward Marschall, Kai‐Chen Wu, Chuan Huang, Munro Passmore, Douglas M. Roberts, David P. Fairlie, Max J. Cryle, Lona M. Alkhalaf, Gregory L. Challis

The paper investigates nitrogen deletion in the biosynthesis of HDAC-targeting anticancer drugs, showing its importance for bioactivity and revealing the enzymatic mechanisms involved.

bioRxiv · Mar 13, 2025 · PreprintBiochemistry