Author

Xinyun Jian

University of WarwickORCID 0000-0002-1276-4396Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:bacteria (other)· 1 Research Focus:drug response / drug discovery· 1 Organism:zebrafish· 1

Frequent Co-Authors

Douglas M. Roberts· 2 shared Gregory L. ChallisiD· 2 shared Lona M. AlkhalafiD· 2 shared Munro PassmoreiD· 2 shared Cheng WangiD· 1 shared Chengbing Qiu· 1 shared Chuan HuangiD· 1 shared Chuan HuangiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersBiochemistry

Douglas M. Roberts

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Molecular basis for depsipeptide HDAC inhibitor combinatorial biosynthesis

Munro Passmore, Xinyun Jian, Xinyi Zhao, Emmanuel L. C. de los Santos, Douglas M. Roberts, Józef Romuald Lewandowski, Matthew Jenner, Lona M. Alkhalaf, Gregory L. Challis

The paper identifies a novel subunit docking mechanism in depsipeptide HDAC inhibitor biosynthesis using gene proximity searching and experimental validation.

Nature Communications · Jul 1, 2026Peer-reviewedBiochemistry

Nitrogen deletion in the biosynthesis of HDAC-targeting anticancer drugs

Xinyun Jian, Jinlian Zhao, Edward Marschall, Kai‐Chen Wu, Chuan Huang, Munro Passmore, Douglas M. Roberts, David P. Fairlie, Max J. Cryle, Lona M. Alkhalaf, Gregory L. Challis

The paper investigates nitrogen deletion in the biosynthesis of HDAC-targeting anticancer drugs, showing its importance for bioactivity and revealing the enzymatic mechanisms involved.

bioRxiv · Mar 13, 2025 · PreprintBiochemistry

Glycodiversification of gentamicins through in vivo glycosyltransferase swapping enabled the creation of novel hybrid aminoglycoside antibiotics with potent activity and low ototoxicity

Xinyun Jian, Cheng Wang, Shijuan Wu, Guo Sun, Chuan Huang, Chengbing Qiu, Yuanzheng Liu, Peter F. Leadlay, Dong Liu, Zixin Deng, Fuling Zhou, Yuhui Sun

This study creates novel hybrid aminoglycoside antibiotics by swapping glycosyltransferases between gentamicin and kanamycin producers, resulting in compounds with potent activity and reduced ototoxicity.

Acta Pharmaceutica Sinica B · May 3, 2024Peer-reviewedSynthetic Biology