Cellular context restricts a promiscuous m6A reader IDR to a single functional effector interface for mRNA decay
Wei Yee Chan, Enkai Jin, Hector Cross, Laura Masino, Fairouz Ibrahim, Waleed S. Albihlal, Duncan Berger, James R. Boot, Aleksandra Michrowska, Stéphane Mouilleron, Mark J. Skehel, Kamil R. Kranc, Folkert Jacobus van Werven
Yeast m6A reader Pho92 uses one helical hydrophobic interface in its disordered region to engage Caf40; a single L35A substitution halts m6A-transcript decay in meiosis.
bioRxiv · Aug 5, 2026 · PreprintMolecular Biology✦ In-depth digest