The regulation of virulence gene expression is controlled by phase separation of heterochromatin protein 1 (HP1) in Plasmodium falciparum
DV Mamatharani, Devatrisha Purkayastha, Igor Niederwieser, Sandeep K. Rai, Prakshi Gaur, Mahipal Ganji, Samrat Mukhopadhyay, Till Steffen Voss, Krishanpal Karmodiya
This study shows that PfHP1 phase separation controls var gene silencing in P. falciparum by forming heterochromatin clusters, leading to antigenic variation.
bioRxiv · Sep 23, 2025 · PreprintMolecular Biology