Abhishek Kanyal

Modulation of host signalling pathways reveal a major role for Wnt signalling in the maturation of Plasmodium falciparum liver schizonts

The paper identifies Wnt signaling as critical for Plasmodium falciparum liver schizont maturation by using a novel medium to maintain hepatocyte functionality and analyze host-parasite interactions.

Jumonji-C domain containing demethylase 1 is critical for heterochromatin organization in Plasmodium falciparum

This study identifies PfJmjC1 as a key regulator of heterochromatin organization in Plasmodium falciparum, showing its role in genome architecture and parasite life cycle.

Protein landscape of the chromatin states in the malaria parasite Plasmodium falciparum

The paper presents a proteomic characterization of chromatin states in Plasmodium falciparum using proximity-labelling approaches, identifying 214 proteins and validating new chromatin components and functions.

The Plasmodium falciparum histone methyltransferase PfSET10 is dispensable for the regulation of antigenic variation and gene expression in blood stage parasites

This study shows that PfSET10 is not required for var gene expression, antigenic variation, or blood stage parasite survival.

Epigenetically-regulated RNA-binding proteins signify malaria hypnozoite dormancy

The paper identifies epigenetically silenced RNA-binding proteins in malaria hypnozoites and proposes they regulate dormancy and reactivation.

Exceptionally high sequence-level variation in the transcriptome of Plasmodium falciparum

The paper identifies high sequence-level variation in the transcriptome of Plasmodium falciparum, including SNVs at rates tenfold higher than bacterial datasets, suggesting intrinsic transcriptional error or RNA editing.