Siglec-7 and -15 recognize repeated clustered sulfo-sialo O-glycan motifs on select O-glycoproteins
Felix Goerdeler, Daniël L. A. H. Hornikx, Vera T.C. Valckx, Yu-Chun Chien, Dylan de Wit, Thapakorn Jaroentomeechai, Martin Jaeger, Sanae Furukawa, Huan-Chuan Tseng, Jaesoo Jung, Edward N. Schmidt, Kay‐Hooi Khoo, Rebecca Louise Miller, Wilfred T.V. Germeraad, Gerard M.J. Bos, , Yoshiki Narimatsu
This study identifies that Siglec-7 and -15 recognize repeated clustered sulfo-sialo O-glycan motifs on specific O-glycoproteins, enhancing selectivity through multivalent interactions.
bioRxiv · Jan 7, 2026 · PreprintMolecular Biology