Author

Yu-Chun Chien

Institute of Biological Chemistry, Academia SinicaORCID 0000-0002-2485-2932Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Research Focus:host-pathogen & immune response· 1 Assay:spatial transcriptomics· 1

Frequent Co-Authors

Kay‐Hooi KhooiD· 2 shared Andrew J. ThompsoniD· 1 shared Ankit BharatiD· 1 shared Anne DelliD· 1 shared Aristotelis AntonopoulosiD· 1 shared Assel BiyashevaiD· 1 shared Chika KikuchiiD· 1 shared Christian BülliD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersMolecular Biology

Kay‐Hooi KhooORCID

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2 papers

Recent·Most cited

Siglec-7 and -15 recognize repeated clustered sulfo-sialo O-glycan motifs on select O-glycoproteins

Felix Goerdeler, Daniël L. A. H. Hornikx, Vera T.C. Valckx, Yu-Chun Chien, Dylan de Wit, Thapakorn Jaroentomeechai, Martin Jaeger, Sanae Furukawa, Huan-Chuan Tseng, Jaesoo Jung, Edward N. Schmidt, Kay‐Hooi Khoo, Rebecca Louise Miller, Wilfred T.V. Germeraad, Gerard M.J. Bos, , Yoshiki Narimatsu

This study identifies that Siglec-7 and -15 recognize repeated clustered sulfo-sialo O-glycan motifs on specific O-glycoproteins, enhancing selectivity through multivalent interactions.

bioRxiv · Jan 7, 2026 · PreprintMolecular Biology

H3N2 influenza virus tropism shifts to glycan receptors on tracheal ciliated cells

Chika Kikuchi, Aristotelis Antonopoulos, Shengyang Wang, Assel Biyasheva, Yu-Chun Chien, Ankit Bharat, Ryan McBride, Corwin M. Nycholat, Andrew J. Thompson, Anne Dell, Kay‐Hooi Khoo, Robert P. Schleimer, Stuart M. Haslam, James C. Paulson

The paper shows H3N2 influenza viruses preferentially bind to tracheal ciliated cells due to specific glycan receptors.

bioRxiv · Sep 12, 2025 · PreprintMicrobiology