Targeting Runx1 protects against heart failure with preserved ejection fraction
Ali Ali Mohamed Elbassioni, Anmar Raheem, Jian Hua Song, Alexander S Johnston, Cara Trivett, Hong Lin, Haobo Zhang, Ashley Bradley, Erin Higgins, Leanne Mooney, Yen Chin Koay, Dylan O’Toole, Pawel Herzyk, Colin Nixon, Karen Blyth, , Eilidh A. MacDonald
This study shows that inhibiting Runx1 protects against heart failure with preserved ejection fraction in mice by improving diastolic function and reducing hypertrophy and pulmonary edema.
bioRxiv · Jan 24, 2025 · PreprintPhysiology