Karen Blyth

Cholesterol and p53 promote senescence and systemic fibrosis in metabolic dysfunction-associated steatohepatitis

This study shows that p53 and cholesterol drive liver fibrosis and systemic fibrosis in MASH, with sex-specific effects in mice.

Glandular architecture and malignant behaviour in colorectal cancer is regulated by the sialomucin Podocalyxin.

This study identifies Podocalyxin as a regulator of glandular architecture in colorectal cancer, showing its role in promoting tumour growth and metastasis.

Runx1 and Runx2 act in concert to suppress Wnt/β-catenin-driven mammary tumourigenesis

This study shows that Runx1 and Runx2 suppress Wnt/β-catenin-driven mammary tumourigenesis, with combined loss leading to increased tumour development and oncogenic pathway activation.

Phenotype-dependent subtyping exposes high MYC activity as a targetable dependency in LuAd

The paper identifies high MYC activity as a targetable feature in lung adenocarcinoma using phenotype-based subtyping and shows sensitivity to a dual inhibitor of MYC co-factors.

Integrin conformation-dependent neutrophil slowing obstructs the capillaries of the pre-metastatic lung in a model of breast cancer

This study shows that integrin conformation-dependent neutrophil slowing in pre-metastatic lungs obstructs capillaries and may contribute to immunosuppression in breast cancer.

Uridine Phosphorylase-1 supports metastasis of mammary cancer by altering immune and extracellular matrix landscapes of the lung

Inactivation of histone chaperone HIRA unmasks a link between normal embryonic development of melanoblasts and maintenance of adult melanocyte stem cells

This study shows that inactivating HIRA during embryonic development affects melanoblasts and leads to aging-related defects in melanocyte stem cells, but not in postnatal melanocytes.

Metabolic adaptations of micrometastases alter EV production to generate invasive microenvironments

The paper shows that breast cancer micrometastases alter metabolism to change extracellular vesicle production, creating an invasive microenvironment.

Biomechanical Compartmentalisation Influences Angiogenesis and Stem Cell Proliferation in the Regenerating Intestine via Vascular Piezo.

This study identifies biomechanical compartmentalization in the regenerating intestine and shows vascular Piezo1 influences angiogenesis and stem cell proliferation across species.

p53 and TIGAR promote redox control to protect against metabolic dysfunction-associated steatohepatitis

This study shows that p53 and TIGAR protect against MASH by controlling redox balance, preventing ROS accumulation, fibrosis, and inflammation.

Loss of ARID1A accelerates prostate tumourigenesis with a proliferative collagen-poor phenotype through co-operation with AP1 subunit cFos

This study identifies Arid1a loss as a driver of aggressive prostate cancer in mice, accelerating tumorigenesis and promoting a proliferative, collagen-poor phenotype through cooperation with cFos.

Targeting Runx1 protects against heart failure with preserved ejection fraction

This study shows that inhibiting Runx1 protects against heart failure with preserved ejection fraction in mice by improving diastolic function and reducing hypertrophy and pulmonary edema.

Caspase-resistant ROCK1 expression prolongs survival of E-mu-Myc B cell lymphoma mice.

This study shows that expressing caspase-resistant ROCK1 in B cell lymphoma mice prolongs survival by reducing cell numbers and creating a proliferation-suppressive bone marrow microenvironment.

RUNX1 marks a luminal castration resistant lineage established at the onset of prostate development

This study identifies RUNX1 as a marker for a castration-resistant luminal lineage in the developing and adult mouse prostate, distinct from NKX3.1+ cells.