A multimodal iPSC platform for cystic fibrosis drug testing
Andrew C. Berical, Rhianna E. Lee, Junjie Lu, Mary Lou Beermann, Jake A. Le Suer, Aditya Mithal, Dylan Thomas, Nicole Ranallo, Megan Peasley, Alexander J. Stuffer, K. Bukis, Rebecca Seymour, Jan Harrington, Kevin J. Coote, Hillary C. Valley, , Finn J Hawkins
This study develops an iPSC platform to test CFTR modulators in cystic fibrosis patients with rare mutations, showing genotype-specific responses to drugs.
Nature Communications · Jul 29, 2022Peer-reviewedDevelopmental Biology