Author

Hillary C. Valley

Cystic Fibrosis Foundation

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Developmental Biology· 1 Genomics· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Jan HarringtoniD· 2 shared Aditya MithaliD· 1 shared Alexander J. StufferiD· 1 shared Andrew C. BericaliD· 1 shared Andrey SivachenkoiD· 1 shared C. Macadino· 1 shared Calvin U. Cotton· 1 shared Dylan Thomas· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersGenomics

Jan HarringtonORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Upregulation of a nonsense mediated decay (NMD) insensitive CFTR mRNA isoform has therapeutic potential for the treatment of 3 Prime CFTR PTC variants

Norm Allaire, M. Armstrong, Jae Seok Yoon, Priyanka Bhatt, Jan Harrington, Yi Cheng, Hillary C. Valley, C. Macadino, Hermann J. Bihler, Andrey Sivachenko, Martin Mense, Calvin U. Cotton

The paper shows that upregulating an NMD-insensitive CFTR mRNA isoform with ASOs and ETI can restore partial Cl- transport function in cells with 3' PTC mutations.

bioRxiv · Jul 1, 2024 · PreprintGenomics

A multimodal iPSC platform for cystic fibrosis drug testing

Andrew C. Berical, Rhianna E. Lee, Junjie Lu, Mary Lou Beermann, Jake A. Le Suer, Aditya Mithal, Dylan Thomas, Nicole Ranallo, Megan Peasley, Alexander J. Stuffer, K. Bukis, Rebecca Seymour, Jan Harrington, Kevin J. Coote, Hillary C. Valley, , Finn J Hawkins

This study develops an iPSC platform to test CFTR modulators in cystic fibrosis patients with rare mutations, showing genotype-specific responses to drugs.

Nature Communications · Jul 29, 2022Peer-reviewedDevelopmental Biology