Gustavo Mostoslavsky

Immunomodulatory RIG-I Agonist SLR14 Confers Protection Against a Range of Highly Pathogenic Negative Sense RNA viruses

SLR14, an immunomodulatory RIG-I agonist, provides broad-spectrum antiviral protection against multiple highly pathogenic negative-sense RNA viruses in vitro and in vivo.

Generation of effector CD4+ T cells from Human iPSC

This paper generates functional CD4+ T cells from human iPSC by modulating Notch signaling, showing cytokine diversity and transcriptional similarity to blood CD4+ T cells.

Expression of Intron-containing HIV-1 RNA Induces NLRP1 Inflammasome Activation in Myeloid Cells

This study shows that HIV-1 intron-containing RNA induces NLRP1 inflammasome activation and IL-1β secretion in myeloid cells through a RLR- and endosomal TLR-independent mechanism.

NMDA receptor misalignment in iPSC-derivedneurons from a multi-generational family withinherited Creutzfeldt-Jakob disease

This study uses iPSC-derived neurons from a family with the E200K prion mutation to model disease-relevant phenotypes, including PrP accumulations and NMDA receptor misalignment.

A multimodal iPSC platform for cystic fibrosis drug testing

This study develops an iPSC platform to test CFTR modulators in cystic fibrosis patients with rare mutations, showing genotype-specific responses to drugs.

DE-NOVO HEMATOPOIESIS FROM THE FETAL LUNG

The paper shows that fetal lung contains hemogenic endothelial cells capable of undergoing endothelial to hematopoietic transition to generate de-novo hematopoietic stem and progenitor cells.

Human iPSC-derived alveolar and airway epithelial cells can be cultured at air-liquid interface and express SARS-CoV-2 host factors

Human iPSC-derived alveolar type II-like and airway epithelial cells adapted to two-dimensional air-liquid interface culture express ACE2 and TMPRSS2 at frequencies comparable to primary lung epithelial controls.

Single-cell time-series mapping of cell fate trajectories reveals an expanded developmental potential for human PSC-derived distal lung progenitors

The paper maps cell fate trajectories of human PSC-derived distal lung progenitors using scRNA-seq and identifies developmental plasticity regulated by Wnt signaling.