Author

Jan Harrington

Cystic Fibrosis FoundationORCID 0009-0001-3237-6737Unclaimed ORCID profile · follow to get notified of new preprints

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Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Hillary C. Valley· 2 shared Aditya MithaliD· 1 shared Alexander J. StufferiD· 1 shared Andrew C. BericaliD· 1 shared Andrey SivachenkoiD· 1 shared C. Macadino· 1 shared Calvin U. Cotton· 1 shared Dylan Thomas· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersGenomics

Hillary C. Valley

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2 papers

Recent·Most cited

Upregulation of a nonsense mediated decay (NMD) insensitive CFTR mRNA isoform has therapeutic potential for the treatment of 3 Prime CFTR PTC variants

Norm Allaire, M. Armstrong, Jae Seok Yoon, Priyanka Bhatt, Jan Harrington, Yi Cheng, Hillary C. Valley, C. Macadino, Hermann J. Bihler, Andrey Sivachenko, Martin Mense, Calvin U. Cotton

The paper shows that upregulating an NMD-insensitive CFTR mRNA isoform with ASOs and ETI can restore partial Cl- transport function in cells with 3' PTC mutations.

bioRxiv · Jul 1, 2024 · PreprintGenomics

A multimodal iPSC platform for cystic fibrosis drug testing

Andrew C. Berical, Rhianna E. Lee, Junjie Lu, Mary Lou Beermann, Jake A. Le Suer, Aditya Mithal, Dylan Thomas, Nicole Ranallo, Megan Peasley, Alexander J. Stuffer, K. Bukis, Rebecca Seymour, Jan Harrington, Kevin J. Coote, Hillary C. Valley, , Finn J Hawkins

This study develops an iPSC platform to test CFTR modulators in cystic fibrosis patients with rare mutations, showing genotype-specific responses to drugs.

Nature Communications · Jul 29, 2022Peer-reviewedDevelopmental Biology