Author

E. A. Birkholz

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:bacteria (other)· 3 Research Focus:cell signaling & trafficking· 3 Research Focus:cell type annotation· 3 Research Focus:protein folding & dynamics· 2 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1 Organism:E. coli· 1

Frequent Co-Authors

E. Villa· 5 shared J. Pogliano· 5 shared K. D. Corbett· 4 shared J. Lee· 3 shared S. Suslov· 3 shared T. G. Laughlin· 3 shared A. Prichard· 2 shared C. J. Morgan· 2 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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5 shared papersMicrobiology

E. Villa

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Author profile →

5 papers

Recent·Most cited

An essential and highly selective protein import pathway encoded by nucleus-forming phage

C. J. Morgan, E. Enustun, E. G. Armbruster, E. A. Birkholz, A. Prichard, T. Forman, A. Aindow, W. Wannasrichan, S. Peters, K. Inlow, I. L. Shepherd, A. Razavilar, V. Chaikeeratisak, B. A. Adler, B. F. Cress, , J. Pogliano

This paper identifies components of a novel protein import pathway in phages, revealing a mechanism for selective protein trafficking into the phage nucleus.

bioRxiv · Mar 21, 2024Microbiology

A mobile intron facilitates interference competition between co-infecting viruses

E. A. Birkholz, C. J. Morgan, T. G. Laughlin, R. K. Lau, A. Prichard, S. Rangarajan, G. N. Meza, J. Lee, E. G. Armbruster, S. Suslov, K. Pogliano, J. R. Meyer, E. Villa, K. D. Corbett, J. Pogliano

The paper shows a mobile intron in bacteriophage ΦPA3 uses its homing endonuclease to interfere with co-infecting phage ΦKZ, providing a competitive reproductive advantage.

bioRxiv · Sep 30, 2023 · PreprintMicrobiology

Architecture and self-assembly of the jumbo bacteriophage nuclear shell

T. G. Laughlin, A. Deep, A. M. Prichard, C. Seitz, Y. Gu, E. Enustun, S. Suslov, K. Khanna, E. A. Birkholz, E. Armbruster, J. A. McCammon, R. E. Amaro, J. Pogliano, K. D. Corbett, E. Villa

The paper identifies chimallin as the primary protein forming the bacteriophage nuclear shell and characterizes its self-assembly into closed compartments.

bioRxiv · Feb 14, 2022Biophysics

A Cytoskeletal Vortex Drives Phage Nucleus Rotation During Jumbo Phage Replication inE. coli

E. A. Birkholz, T. G. Laughlin, S. Suslov, E. Armbruster, J. Lee, J. Wittmann, K. D. Corbett, E. Villa, J. Pogliano

The paper identifies a cytoskeletal vortex in E. coli jumbo phage Goslar that drives phage nucleus rotation, similar to eukaryotic structures.

bioRxiv · Oct 25, 2021Microbiology

Selective transport of fluorescent proteins into the phage nucleus

K. T. Nguyen, J. Sugie, K. Khanna, E. E. MacKennon, E. A. Birkholz, J. Lee, C. Beierschmitt, E. Villa, J. Pogliano

The paper investigates nuclear transport in phage infection systems, finding that GFPmut1 can be selectively transported into the {Phi}KZ phage nucleus, with specific amino acid residues identified for this process.

bioRxiv · Nov 25, 2020Microbiology