K. D. Corbett

Bacteriophage {Phi}21s receptor-binding protein evolves new functions through destabilizing mutations that generate non-genetic phenotypic heterogeneity

This study shows that bacteriophage Φ21 evolves new host receptor usage through destabilizing mutations that create non-genetic phenotypic heterogeneity in viral particles.

An essential and highly selective protein import pathway encoded by nucleus-forming phage

This paper identifies components of a novel protein import pathway in phages, revealing a mechanism for selective protein trafficking into the phage nucleus.

Phospho-KNL-1 recognition by a TPR domain targets the BUB-1/BUB-3 complex to C. elegans kinetochores

This study shows that the BUB-1 TPR domain directly binds phosphorylated KNL-1 motifs, essential for BUB-1-BUB-3 localization and function in C. elegans.

Architecture and infection-sensing mechanism of the bacterial PARIS defense system

This study reveals the molecular architecture and infection-sensing mechanism of the bacterial PARIS defense system, showing how it is triggered by a phage counterdefense protein.

Phosphorylation regulates tau's phase separation behavior and interactions with chromatin

This study shows phosphorylation disrupts tau's ability to undergo phase separation and interact with chromatin, potentially contributing to nuclear dysfunction in Alzheimer's disease.

A mobile intron facilitates interference competition between co-infecting viruses

The paper shows a mobile intron in bacteriophage ΦPA3 uses its homing endonuclease to interfere with co-infecting phage ΦKZ, providing a competitive reproductive advantage.

Bacterial antiviral defense pathways encode eukaryotic-like ubiquitination systems

This study shows bacteria have a complete ubiquitination pathway similar to eukaryotes, with structural and functional parallels to eukaryotic systems.

A phage nucleus-associated RNA-binding protein is required for jumbo phage infection

This study identifies ChmC, a phage protein that binds RNA and facilitates mRNA transport through the phage nucleus-like compartment, essential for infection.

A transcriptionally active lipid vesicle encloses theinjected Chimalliviridae genome in early infection

The paper shows that Chimalliviridae form a lipid membrane-bound EPI vesicle during early infection, which hosts transcription of the phage genome, and demonstrates the necessity of a second compartment, the phage nucleus, for genome replication.

Bacterial Shedu immune nucleases share a common enzymatic core regulated by diverse sensor domains

The paper identifies the structural basis for activation of Bacillus cereus Shedu nuclease and reveals diversity in its N-terminal regulatory domains across 8,000 homologs.

Identification of the bacteriophage nucleus protein interaction network

The paper identifies proteins interacting with the phage nucleus protein ChmA and describes their potential roles in genome packaging and transport.

Chromatin binding by HORMAD proteins regulates meiotic recombination initiation

This study shows that HORMAD proteins bind chromatin to regulate meiotic recombination initiation in yeast.

PLK-1 tethered on BUB-1 directs CDC-20 kinetochore recruitment to ensure timelyembryonic mitoses

This study shows that PLK-1 tethered on BUB-1 promotes CDC-20 recruitment to kinetochores, ensuring timely mitosis in C. elegans embryos through phosphoregulation.

The conserved AAA-ATPase PCH-2 distributes its regulation of meiotic prophase events by remodeling multiple meiotic HORMADs in C. elegans

This study shows PCH-2 remodels meiotic HORMADs in C. elegans to regulate homolog pairing, synapsis, and recombination, ensuring accurate meiotic progression.

A conserved signaling pathway activates bacterial CBASS immune signaling in response to DNA damage

The paper identifies a conserved signaling pathway in bacteria that activates CBASS immune systems in response to DNA damage through the regulation of CapH and CapP.

cGASylation by a bacterial E1-E2 fusion protein primes antiviral immune signaling

The paper shows that a bacterial E1-E2 fusion protein, Cap2, primes cGAS for antiviral signaling through a process called cGASylation, which increases cGAMP production by ~50-fold.

Architecture and self-assembly of the jumbo bacteriophage nuclear shell

The paper identifies chimallin as the primary protein forming the bacteriophage nuclear shell and characterizes its self-assembly into closed compartments.

Control of bacterial immune signaling by a WYL domain transcription factor

The paper identifies CapW, a transcription factor that regulates CBASS gene expression in bacteria, showing it represses the system in uninfected cells and is activated by phage infection, though not required for anti-phage activity.

A Cytoskeletal Vortex Drives Phage Nucleus Rotation During Jumbo Phage Replication inE. coli

The paper identifies a cytoskeletal vortex in E. coli jumbo phage Goslar that drives phage nucleus rotation, similar to eukaryotic structures.

Structural basis for SARS-CoV-2 Nucleocapsid protein recognition by single-domain antibodies

This study reports high-resolution crystal structures of three llama-derived single-domain antibodies that bind the SARS-CoV-2 Nucleocapsid protein, revealing conserved binding sites for potential diagnostic applications.

SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2

This study shows SARS-CoV-2 spike protein binds to heparan sulfate and ACE2 on cells codependently, forming a complex that facilitates infection, suggesting potential therapeutic targets.

The SARS-CoV-2 Nucleocapsid phosphoprotein forms mutually exclusive condensates with RNA and the membrane-associated M protein

This study shows the SARS-CoV-2 N protein forms distinct condensates with RNA and M protein, aiding viral RNA packaging and virion assembly.

Phosphoregulation of HORMA domain protein HIM-3 promotes asymmetric synaptonemal complex disassembly in meiotic prophase in C. elegans

This study shows that phosphorylation of HIM-3, a HORMA domain protein, regulates asymmetric synaptonemal complex disassembly in C. elegans meiosis by modulating its interaction with HTP-1 and HTP-2.

Architecture and self-assembly of the SARS-CoV-2 nucleocapsid protein

This study determines the structure and self-assembly of the SARS-CoV-2 nucleocapsid protein, identifies structured regions in disordered domains, and maps amino acid substitutions across viral genomes.

HORMA domain proteins and a Pch2-like ATPase regulate bacterial cGAS-like enzymes to mediate bacteriophage immunity

The paper identifies a bacterial immunity pathway involving HORMA domain proteins, a cGAS-like enzyme, and a Pch2-like ATPase that mediates bacteriophage defense by generating a cyclic tri-AMP second messenger.

The Molecular Basis of Monopolin Recruitment to the Kinetochore

This paper identifies the molecular mechanisms by which the monopolin complex binds to the kinetochore protein Dsn1 in budding yeast, revealing two distinct binding motifs and their functional roles in meiosis I.

Structure of Zip2:Spo16, a conserved XPF:ERCC1-like complex critical for meiotic crossover formation

The paper determines the structure of the Zip2:Spo16 complex, showing it binds DNA structures in meiotic recombination and is critical for crossover formation.