E. A. Klein

Spatial organization of bacterial sphingolipid synthesis enzymes

The paper investigates the subcellular localization of bacterial sphingolipid synthesis enzymes to determine the order of reactions in the pathway.

Characterization of an evolutionarily distinct bacterial ceramide kinase from Caulobacter crescentus

This study characterizes CpgB, a bacterial ceramide kinase from Caulobacter crescentus, showing it phosphorylates ceramide to form ceramide 1-phosphate with specific kinetic and cofactor requirements.

Caulobacter requires anionic sphingolipids and deactivation of fur to lose lipid A

This study identifies that Caulobacter requires anionic sphingolipids and deactivation of Fur to survive without lipid A in its outer membrane.

Sex, androgens and regulation of pulmonary AR, TMPRSS2 and ACE2

This study investigates sex differences in TMPRSS2 and ACE2 expression in human and mouse lungs and evaluates the effect of anti-androgens on these genes, finding no significant increase in TMPRSS2 but sex dimorphism in ACE2.

Sugar-phosphate metabolism regulates stationary phase entry and stalk elongation in Caulobacter crescentus

This study identifies mutations in the phosphomannose isomerase gene (manA) that block stalk elongation in Caulobacter crescentus, revealing a role for sugar-phosphate metabolism in regulating stalk synthesis independent of phosphate starvation.

AimB is a small protein regulator of cell size and MreB assembly

This study identifies AimB as a small protein that inhibits MreB polymerization in Caulobacter crescentus, leading to altered cell shape and MreB delocalization.