Sex, androgens and regulation of pulmonary AR, TMPRSS2 and ACE2
M. Baratchian, J. McManus, M. Berk, F. Nakamura, S. Mukhopadhyay, W. Xu, S. Erzurum, S. Mukhopadhyay, J. Drazba, J. Peterson, E. A. Klein, B. Gaston, N. Sharifi
This study investigates sex differences in TMPRSS2 and ACE2 expression in human and mouse lungs and evaluates the effect of anti-androgens on these genes, finding no significant increase in TMPRSS2 but sex dimorphism in ACE2.
bioRxiv · Apr 21, 2020Physiology