E. Akalestou

Effects of SGLT2 Ablation or Inhibition on Corticosterone Secretion in High-Fat-Fed Mice: Exploring a Nexus with Cytokine Levels

This study investigates the effects of SGLT2 inhibition or deletion on corticosterone secretion and cytokine levels in high-fat-fed mice, revealing links between SGLT2 activity, immune modulation, and metabolic homeostasis.

Bariatric surgery normalizes circulating glucocorticoid levels and lowers glucocorticoid action tissue-selectively in mice

This study shows bariatric surgery lowers glucocorticoid levels and reduces tissue-specific glucocorticoid activity in mice, improving insulin sensitivity without significant weight loss.

Intravital imaging of islet Ca2+ dynamics reveals enhanced β cell connectivity after bariatric surgery in mice

This study uses intravital imaging to show that bariatric surgery enhances β cell connectivity and Ca2+ dynamics in mice, leading to improved glucose tolerance and insulin secretion.

Vertical sleeve gastrectomy lowers kidney SGLT2 expression in the mouse

This study shows that vertical sleeve gastrectomy reduces kidney SGLT2 expression in mice, which may explain improved glucose tolerance after bariatric surgery.

The homeostatic dynamics of feeding behaviour identify novel mechanisms of anorectic agents

This study develops a stochastic model of rodent feeding behavior to analyze how anorectic agents affect feeding patterns and reveals that these agents do not mimic satiety.