Author

V. Salem

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4 Physiology· 2 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 6 Approach:experimental assay· 5 Research Focus:cell signaling & trafficking· 4 Assay:proteomics· 3 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2

Frequent Co-Authors

G. A. Rutter· 5 shared K. Suba· 4 shared A. Tomas· 3 shared B. Jones· 3 shared S. R. Bloom· 3 shared W. Distaso· 3 shared B. Hansen· 2 shared D. Hodson· 2 shared

Activity by Year

2020-2022 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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5 shared papersCell Biology

G. A. Rutter

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Intra-islet glucagon signalling regulates pulsatile insulin secretion and glucose homeostasis

K. Suba, Y. Patel, A. M. Alonso, A. Roberts, B. Hansen, M. Norton, J. Shrewsbury, R. Kwok, V. Kalogianni, S. Chen, X. Liu, G. A. Rutter, B. Jones, J. Minnion, B. M. Owen, , V. Salem

This study shows that loss of intra-islet glucagon receptor signaling impairs glucose tolerance and insulin pulsatility in mice, suggesting glucagonergic agents could restore insulin pulsatility in T2D.

bioRxiv · Sep 1, 2022 · PreprintPhysiology

Divergent acute versus prolonged pharmacological GLP-1R responses in adult beta cell-selective β-arrestin 2 knockout mice

S. Bitsi, Y. Manchanda, L. ElEid, N. Mohamed, B. Hansen, K. Suba, G. A. Rutter, V. Salem, B. Jones, A. Tomas

This study examines GLP-1R responses in beta cell-specific β-arrestin 2 knockout mice, finding acute deficits and prolonged effects with certain agonists.

bioRxiv · Apr 21, 2022 · PreprintCell Biology

Evaluation of efficacy- versus affinity-driven agonism with biased GLP-1R ligands P5 and exendin-F1

A. Marzook, S. Chen, P. Pickford, M. Lucey, Y. Wang, I. R. Correa, J. Broichhagen, D. Hodson, V. Salem, G. A. Rutter, T. M. Tan, S. R. Bloom, A. Tomas, B. Jones

This study compares the efficacy and affinity of two GLP-1R agonists, P5 and exendin-F1, showing that exendin-F1's lower acute efficacy correlates with sustained insulin secretion and anti-hyperglycaemic effects.

bioRxiv · Apr 1, 2021Pharmacology & Toxicology

The type 2 diabetes gene product STARD10 is a phosphoinositide binding protein that controls insulin secretory granule biogenesis

G. R. Carrat, E. Haythorne, A. Tomas, L. Haataja, A. Mueller, P. Arvan, A. Piunti, K. Cheng, M. Huang, T. Pullen, E. Georgiadou, T. Stylianides, N. S. Amirruddin, V. Salem, W. Distaso, , G. A. Rutter

This study identifies STARD10 as a phosphoinositide binding protein that regulates insulin granule biogenesis in beta-cells by affecting phosphatidylinositol levels and proinsulin processing.

Molecular Metabolism · Oct 1, 2020Peer-reviewedCell Biology

The Vagus Nerve Mediates the Physiological but not Pharmacological Effects of PYY3-36 on Food Intake

A. Martin Alonso, S. C. Cork, Y. Ma, M. Arnold, H. Herzog, S. R. Bloom, W. Distaso, K. Murphy, V. Salem

This study shows that PYY3-36's physiological effects on food intake depend on the vagus nerve's Y2R, but pharmacological effects are not affected.

bioRxiv · Aug 7, 2020Physiology

Intravital imaging of islet Ca2+ dynamics reveals enhanced β cell connectivity after bariatric surgery in mice

E. Akalestou, K. Suba, L. Lopez-Noriega, E. Georgiadou, P. Chabosseau, I. Leclerc, V. Salem, G. A. Rutter

This study uses intravital imaging to show that bariatric surgery enhances β cell connectivity and Ca2+ dynamics in mice, leading to improved glucose tolerance and insulin secretion.

bioRxiv · May 5, 2020Cell Biology

Arginine-vasopressin mediates counter-regulatory glucagon release and is diminished in type 1 diabetes

A. Kim, J. G. Knudsen, J. C. Madara, A. Benrick, T. Hill, L. Abdul Kadir, J. A. Kellard, L. Mellander, C. Miranda, H. Lin, T. James, K. Suba, A. Spigelman, Y. Wu, P. MacDonald, , L. Briant

This study identifies arginine-vasopressin as a systemic regulator of glucagon secretion, showing its role in counter-regulatory responses to hypoglycemia and its impairment in type 1 diabetes.

bioRxiv · Jan 30, 2020Cell Biology