I. Leclerc

Molecular phenotyping of single pancreatic islet leader beta cells by Flash-Seq

The paper identifies leader beta cells in pancreatic islets using Flash-Seq and finds they have a distinct transcriptome and localization compared to follower cells.

Bariatric surgery normalizes circulating glucocorticoid levels and lowers glucocorticoid action tissue-selectively in mice

This study shows bariatric surgery lowers glucocorticoid levels and reduces tissue-specific glucocorticoid activity in mice, improving insulin sensitivity without significant weight loss.

Roles for the long non-coding RNA Pax6os1/PAX6-AS1 in pancreatic beta cell identity and function.

This study investigates the role of Pax6os1/PAX6-AS1 in beta cell identity and function, finding that its upregulation in diabetes contributes to impaired functionality and that targeting it may improve glucose homeostasis.

Reduced expression of TCF7L2 in adipocyte impairs glucose tolerance associated with decreased insulin secretion, incretins levels and lipid metabolism dysregulation in male mice

This study shows that reducing TCF7L2 in adipocytes impairs glucose tolerance in male mice through decreased insulin secretion, incretins, and lipid metabolism dysregulation, with effects dependent on gender, age, and diet.

Intravital imaging of islet Ca2+ dynamics reveals enhanced β cell connectivity after bariatric surgery in mice

This study uses intravital imaging to show that bariatric surgery enhances β cell connectivity and Ca2+ dynamics in mice, leading to improved glucose tolerance and insulin secretion.

Sorcin stimulates Activation Transcription Factor 6α (ATF6) transcriptional activity

This study shows that sorcin enhances ATF6 transcriptional activity, which is reduced during lipotoxic stress and contributes to beta cell failure in type 2 diabetes.

The type 2 diabetes gene product STARD10 is a phosphoinositide binding protein that controls insulin secretory granule biogenesis

This study identifies STARD10 as a phosphoinositide binding protein that regulates insulin granule biogenesis in beta-cells by affecting phosphatidylinositol levels and proinsulin processing.

The mitochondrial Ca2+ uniporter MCU is required for normal glucose-stimulated insulin secretion in vitro and in vivo

This study shows that the mitochondrial Ca2+ uniporter MCU is essential for normal glucose-stimulated insulin secretion in pancreatic beta-cells, both in vitro and in vivo.

Vertical sleeve gastrectomy lowers kidney SGLT2 expression in the mouse

This study shows that vertical sleeve gastrectomy reduces kidney SGLT2 expression in mice, which may explain improved glucose tolerance after bariatric surgery.