Comparing the value of mono- versus coculture for high-throughput compound screening in hematological malignancies
S. A. Herbst, V. Kim, T. Roider, E. C. Schitter, P.-M. Bruch, N. Liebers, C. Kolb, M. Knoll, J. Lu, P. Dreger, C. Mueller-Tidow, T. Zenz, W. Huber, S. Dietrich
This study compares monoculture and stromal coculture for drug screening in hematological malignancies, finding that coculture reduces drug efficacy for many compounds but increases it for JAK inhibitors.
bioRxiv · Feb 18, 2022Cancer Biology