M. Knoll

Multimodal and spatially resolved profiling identifies distinct patterns of T-cell infiltration in nodal B-cell lymphoma entities

A single-cell multi-omic and spatial atlas of B cell lymphomas reveals differentiation drives intratumor heterogeneity

This study reveals that cellular differentiation drives intratumor heterogeneity in B-cell lymphomas, with distinct maturation states associated with different survival outcomes.

Host obesity impacts genetic variation in influenza A viral populations

This study investigates how host obesity affects genetic variation in influenza A virus populations using a ferret model, finding enhanced positive selection and host-specific mutations in obese hosts.

Proteomic profiling identifies Serpin B9 as mediator of resistance to CAR T-cell and bispecific antibody treatment in B-cell lymphoma

Reprogramming M2-polarized patient-derived glioblastoma associated microglia/macrophages via CSF1R inhibition

This study shows that GW2580 reprograms M2-like glioblastoma-associated macrophages to M1-like cells, enhancing phagocytosis and T-cell killing, and reduces tumor cell proliferation in patient-derived organoids.

Proteogenomics refines the molecular classification of chronic lymphocytic leukemia

The paper performs a proteogenomic analysis of chronic lymphocytic leukemia, identifies a new poor-prognosis subgroup (ASB-CLL) through proteomic profiling, and links it to clinical outcomes.

Comparing the value of mono- versus coculture for high-throughput compound screening in hematological malignancies

This study compares monoculture and stromal coculture for drug screening in hematological malignancies, finding that coculture reduces drug efficacy for many compounds but increases it for JAK inhibitors.

Optimized Quantification of Intrahost Viral Diversity in SARS-CoV-2 and Influenza Virus Sequence Data

This study evaluates variant calling tools for detecting minority variants in viral sequencing data and provides guidance for accurate quantification of intrahost viral diversity.

An adipocyte-specific lncRAP2 - Igf2bp2 complex enhances adipogenesis and energy expenditure by stabilizing target mRNAs

This study identifies the lncRAP2-Igf2bp2 complex as a regulator of adipogenesis and energy expenditure by stabilizing target mRNAs, with implications for obesity and type 2 diabetes.