S. Dietrich

Multimodal and spatially resolved profiling identifies distinct patterns of T-cell infiltration in nodal B-cell lymphoma entities

A single-cell multi-omic and spatial atlas of B cell lymphomas reveals differentiation drives intratumor heterogeneity

This study reveals that cellular differentiation drives intratumor heterogeneity in B-cell lymphomas, with distinct maturation states associated with different survival outcomes.

Proteomic profiling identifies Serpin B9 as mediator of resistance to CAR T-cell and bispecific antibody treatment in B-cell lymphoma

High-dimensional single-cell definition of CLL T cells identifies Galectin-9 as novel immunotherapy target

The paper defines CLL T cell subtypes and identifies Galectin-9 as a novel immunotherapy target through single-cell and multi-omics analyses.

A heterogeneous pool of tumor precursor cells with self-replenishing and tumor-originating properties in Chronic Lymphocytic Leukemia

The paper identifies a heterogeneous subpopulation of CLL-related B cells with self-replenishing and tumor-initiating properties that contribute to disease progression and clonal evolution.

Pre-analytical processing of plasma and serum samples for combined proteome and metabolome analysis

This study evaluates pre-analytical factors affecting plasma and serum proteome and metabolome stability, recommending standardized protocols for clinical use.

Comparing the value of mono- versus coculture for high-throughput compound screening in hematological malignancies

This study compares monoculture and stromal coculture for drug screening in hematological malignancies, finding that coculture reduces drug efficacy for many compounds but increases it for JAK inhibitors.

G6b-B regulates an essential step in megakaryocyte maturation

This study identifies G6b-B's critical role in early megakaryocyte differentiation by analyzing a mouse model with a mutation causing macrothrombocytopenia and myelofibrosis.

Combinatorial drug-microenvironment interaction mapping reveals cell-extrinsic drug resistance mechanisms and clinically relevant patient subgroups in CLL

This paper maps drug-microenvironment interactions in CLL to identify resistance mechanisms and patient subgroups, revealing how microenvironmental stimuli and genetic alterations influence drug response.

A synergistic interaction between HDAC- and PARP inhibitors in childhood tumors with chromothripsis

The paper identifies a synergistic effect between HDAC and PARP inhibitors in childhood tumors with chromothripsis, validated through drug screening and in vivo models.

Phagocytosis by stroma confounds co-culture studies

The paper shows that bone marrow stromal cells can phagocytose apoptotic cells, potentially leading to misinterpretation of drug response in co-culture studies.

EOMES and IL-10 regulate anti-tumor activity of PD-1+ CD4+ T-cells in B-cell Non-Hodgkin lymphoma

Dissecting intratumor heterogeneity of nodal B cell lymphomas on the transcriptional, genetic, and drug response level

This study examines intratumor heterogeneity in B cell lymphomas by analyzing transcriptional, genetic, and drug response profiles across malignant subclones and immune cells.