Author

S. A. Herbst

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:drug response / drug discovery· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1

Frequent Co-Authors

C. Kolb· 4 shared J. Lu· 3 shared P. Dreger· 3 shared P.-M. Bruch· 3 shared S. Dietrich· 3 shared T. Roider· 3 shared T. Zenz· 3 shared C. Mueller-Tidow· 2 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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4 shared papersCancer Biology

C. Kolb

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4 papers

Recent·Most cited

Proteogenomics refines the molecular classification of chronic lymphocytic leukemia

S. A. Herbst, M. Vesterlund, A. J. Helmboldt, R. Jafari, I. Siavelis, M. Stahl, E. Schitter, N. Liebers, B. Brinkmann, F. Czernilofsky, T. Roider, P.-M. Bruch, M. Iskar, A. Kittai, Y. Huang, , Hu

The paper performs a proteogenomic analysis of chronic lymphocytic leukemia, identifies a new poor-prognosis subgroup (ASB-CLL) through proteomic profiling, and links it to clinical outcomes.

bioRxiv · Mar 1, 2022Cancer Biology

Comparing the value of mono- versus coculture for high-throughput compound screening in hematological malignancies

S. A. Herbst, V. Kim, T. Roider, E. C. Schitter, P.-M. Bruch, N. Liebers, C. Kolb, M. Knoll, J. Lu, P. Dreger, C. Mueller-Tidow, T. Zenz, W. Huber, S. Dietrich

This study compares monoculture and stromal coculture for drug screening in hematological malignancies, finding that coculture reduces drug efficacy for many compounds but increases it for JAK inhibitors.

bioRxiv · Feb 18, 2022Cancer Biology

Combinatorial drug-microenvironment interaction mapping reveals cell-extrinsic drug resistance mechanisms and clinically relevant patient subgroups in CLL

P.-M. Bruch, H. A. R. Giles, C. Kolb, S. A. Herbst, T. Becirovic, T. Roider, J. Lu, S. Scheinost, L. Wagner, J. Huellein, I. Berest, M. Kriegsmann, K. Kriegsmann, C. Zgorzelski, P. Dreger, , S. Dietrich

This paper maps drug-microenvironment interactions in CLL to identify resistance mechanisms and patient subgroups, revealing how microenvironmental stimuli and genetic alterations influence drug response.

bioRxiv · Jul 23, 2021 · PreprintCancer Biology

Phagocytosis by stroma confounds co-culture studies

S. A. Herbst, M. Stolarczyk, T. Becirovic, Y. Liu, C. Kolb, M. Herling, C. Müller-Tidow, S. Dietrich

The paper shows that bone marrow stromal cells can phagocytose apoptotic cells, potentially leading to misinterpretation of drug response in co-culture studies.

bioRxiv · Dec 11, 2020 · PreprintCancer Biology