Senescent stromal cells promote cancer resistance through SIRT1 loss-potentiated overproduction of small extracellular vesicles
L. Han, Q. Long, S. Li, Q. Xu, B. Zhang, X. Dou, M. Qian, Y. Jiramongkol, J. Guo, L. Cao, E. Chin, E. Lam, J. Jiang, Y. Sun
This study shows senescent stromal cells release sEVs that promote cancer drug resistance via SIRT1 loss, and suggests targeting SIRT1 could prevent this resistance.
bioRxiv · Mar 22, 2020Cell Biology