M. Qian

PbrSYP71 regulates pollen tube growth by maintaining uneven distribution of the ER in Pyrus

This study identifies PbrSYP71 as a pollen tube-specific syntaxin that maintains uneven ER distribution by tethering ER to F-actin, promoting pollen tube growth in pear.

Akkermansia muciniphila identified as key strain to alleviate gut barrier injury through Wnt signaling pathway

This study identifies Akkermansia muciniphila as a key strain in fecal microbiota transplantation that alleviates gut barrier injury by modulating the Wnt/β-catenin signaling pathway in an ETEC infection model.

Genetically engineered mesenchymal stem cells as a nitric oxide reservoir for acute kidney injury therapy

This paper genetically engineers mesenchymal stem cells to act as a nitric oxide reservoir, enhancing therapeutic efficiency in acute kidney injury by precise spatiotemporal NO release.

YAP-controlled MHC I and CXCL10 expression potentiates antitumor immunity independently of IFNγ signaling

This study shows that inhibiting YAP in tumor cells enhances MHC-I and CXCL10 expression, boosting antitumor immunity and improving response to anti-PD1 therapy without requiring IFNγ signaling.

Sequencing uracil in DNA at single-nucleotide resolution

This paper introduces SNU-seq, a method for single-nucleotide uracil mapping in DNA, validated on synthetic DNA and mammalian genomes, revealing uracil dynamics in treated cells and AID hotspots.

KDM4 Orchestrates Epigenomic Remodeling of Senescent Cells and Potentiates the Senescence-Associated Secretory Phenotype

This study shows KDM4 promotes epigenomic changes in senescent cells, enhances the SASP, and presents a therapeutic target for age-related diseases.

Downsizing in plants - UV induces pronounced morphological changes in cucumber in the absence of stress

This study shows UV-A and UV-B light induce distinct morphological changes in cucumber without causing stress, indicating regulatory adjustments in UV acclimation.

4 β-hydroxycholesterol is a pro-lipogenic factor that promotes SREBP1c expression and activity through Liver X-receptor.

This study identifies 4β-hydroxycholesterol as a pro-lipogenic factor that activates SREBP1c via LXR to promote de novo lipogenesis.

Senescent stromal cells promote cancer resistance through SIRT1 loss-potentiated overproduction of small extracellular vesicles

This study shows senescent stromal cells release sEVs that promote cancer drug resistance via SIRT1 loss, and suggests targeting SIRT1 could prevent this resistance.

Synergy between SIRT1 and SIRT6 helps recognize DNA breaks and potentiate the DNA damage response and repair

This study shows that SIRT1 and SIRT6 work together to recognize DNA breaks and enhance the DNA damage response and repair.

Exponential Growth of Glioblastoma In Vivo Driven by Rapidly Dividing and Outwardly Migrating Cancer Stem Cells

This study identifies that glioblastoma grows exponentially due to symmetric divisions of brain tumor stem cells (BTSCs) accumulating at the tumor rim.

Novel 3,6-Dihydroxypicolinic Acid Decarboxylase Mediated Picolinic Acid Catabolism in Alcaligenes faecalis JQ135

This study identifies and characterizes a novel decarboxylase, PicC, involved in the catabolism of picolinic acid in Alcaligenes faecalis JQ135, demonstrating its role in converting 3,6-dihydroxypicolinic acid to 2.5-dihydroxypyridine.