The SARS-CoV-2 conserved macrodomain is a mono-ADP-ribosylhydrolase
Y. M. O. Alhammad, M. M. Kashipathy, A. Roy, J.-P. Gagne, P. McDonald, P. Gao, L. Nonfoux, K. P. Battaile, D. K. Johnson, E. D. Holmstrom, G. G. Poirier, S. W. Lovell, A. R. Fehr
This paper identifies SARS-CoV-2's Mac1 as a mono-ADP-ribosylhydrolase, showing it binds and hydrolyzes mono-ADP-ribose, with implications for antiviral therapy.
bioRxiv · May 11, 2020Biochemistry